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Warning Text %XTableStyleMedium2PivotStyleLight16`4)Current products list 嗎Sheet18 HCatalogue numberName Volumn (mL) Price ($) DescriptionCategory Details Product URLF101027Plain DPPC/CHOL Liposomes (55:45 mol/mol, 100 nm, 60mM)F101037Plain DSPC/CHOL Liposomes (55:45 mol/mol, 100 nm, 60mM)F101046Plain HSPC/CHOL Liposomes (55:45 mol/mol, 100 nm,60mM)F101059Plain 20:0PC/CHOL Liposomes (55:45 mol/mol, 100 nm, 60mM)F10109(Plain Pure DOPC Liposomes (100 nm, 60mM)F10110(Plain Pure POPC Liposomes (100 nm, 60mM)F10202GPlain DPPC/CHOL/mPEG2000-DSPE Liposomes (50:45:5 mol/mol, 100 nm, 60mM)F10203GPlain DSPC/CHOL/mPEG2000-DSPE Liposomes (50:45:5 mol/mol, 100 nm, 60mM)F10204GPlain HSPC/CHOL/mPEG2000-DSPE Liposomes (50:45:5 mol/mol, 100 nm, 60mM)F10205IPlain 20:0PC/CHOL/mPEG2000-DSPE Liposomes (50:45:5 mol/mol, 100 nm, 60mM)F20103ACDSPC/CHOL (55:45 mol/mol) Liposomes with Ammonium Gradient (100nm)F20104ACHSPC/CHOL (55:45 mol/mol) Liposomes with Ammonium Gradient (100nm)F20203AODSPC/CHOL/mPEG-DSPE (50:45:5 mol/mol) Liposomes with Ammonium Gradient (100nm)F20204ARHSPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol) Liposomes with Ammonium Gradient (100nm)F20204ABPHSPC/CHOL/mPEG2000-DSPE (56.2/38.5/5.3) Liposomes with Ammonium Gradient (100nm)F20204ASTSUV HSPC/CHOL/mPEG2000-DSPE (56.2/38.5/5.3) Liposomes with Ammonium Gradient (80 nm)8Doxoves - STEALTH Liposomal Doxorubicin HCl (4.0mg/mL) 6STEALTH Liposomal Irinotecan HCl (2.0mg/mL, 80-100nm) 5STEALTH Liposomal Topotecan HCl (2.0mg/mL, 80-100nm) F50101Cationic Liposomes DMTAP/DOPEF50102Cationic Liposomes DOTAP/DOPEF50103Cationic Liposomes DDAB/DOPEF50104Cationic Liposomes DODAP/DOPEF50105Cationic Liposomes DC-CHOL/DOPE3Placebo Control for fluorescent DOPC/CHOL Liposomes$DOPC/CHOL Liposomes labeled with DiI2 DOPC/CHOL Liposomes labeled with Fluorescein DHPE1DOPC/CHOL Liposomes labeled with Marina Blue-DHPE'DOPC/CHOL Liposomes Labeled with NBD-PE6DOPC/CHOL Liposomes labeled with Oregon Green 488 DHPE/DOPC/CHOL Liposomes labeled with Rhodamine DHPE+DOPC/CHOL Liposomes labeled with TRITC-DHPE/DOPC/CHOL Liposomes labeled with Texas Red DHPE F60203F-D F60203F-F< DOPC/CHOL/mPEG-DSPE Liposomes labeled with Fluorescein DHPE F60203F-MB;DOPC/CHOL/mPEG-DSPE Liposomes labeled with Marina Blue-DHPE F60203F-NBD1DOPC/CHOL/mPEG-DSPE Liposomes Labeled with NBD-PE F60203F-OG@DOPC/CHOL/mPEG-DSPE Liposomes labeled with Oregon Green 488 DHPE F60203F-R=DOPC/CHOL/mPEG2000-DSPE Liposomes labeled with Rhodamine DHPE F60203F-TC5DOPC/CHOL/mPEG-DSPE Liposomes labeled with TRITC-DHPE F60203F-TR9DOPC/CHOL/mPEG-DSPE Liposomes labeled with Texas Red DHPEF60203-P,Placebo Control DOPC/CHOL/PEG-DSPE Liposomes.Clophosome-A - Clodronate Liposomes (Anionic)*Combo: Clophosome-A and Control Liposomes4Clophosome-A, Fluorescent & Plain Control LiposomeshAll-In-One Combo Kit: Clophosome-A (anionic), Clophosome-N (neutral) - And Control Liposomes for both F70101C-NASFEvaluation Samples: Clophosome (neutral) and Clophosome-A (anionic)4Combo: Clophosome-N (neutral) and Control LiposomesFCombo: Clophosome-N (neutrral), Fluorescent & Plain Control Liposomes9Fluorescent Control Liposomes for Clophosome-A (anionic)7Fluorescent Control Liposomes for Clophosome (neutral)FB30020Dilution Buffer for Doxoves Plain DSPC/CHOL liposomes (55:45 mol/mol, 100 nm) Lipid composition: DSPC/CHOL (55:45 mol/mol) Mean particle size: 100 nm (95 - 120 nm) Lipid concentration: 60 mM (60-65 mM) Internal/External solution: 10% sucrose, 20 mM HEPES, pH 7.0 - 7.5Plain DPPC/CHOL Liposomes (55:45 mol/mol, 100 nm, 60mM) Lipid composition: DPPC/CHOL (55:45 mol/mol) Mean particle size: 100 nm (95 - 120 nm) Lipid concentration: 60 mM (60 -65 mM) Internal/External solution: 10% sucrose, 20 mM HEPES, pH 7.0 - 7.5 Plain HSPC/CHOL liposomes (55:45 mol/mol, 100 nm) Product code: F10104 Lipid composition: HSPC/CHOL (55:45 mol/mol) Mean particle size: 100 nm (95 - 120 nm) Lipid concentration: 60 mM (60 -65 mM) Internal/External solution: 10% sucrose, 20 mM HEPES, pH 7.0 - 7.5Plain 20:0PPC/CHOL liposomes (55:45 mol/mol, 100 nm) Lipid composition: 20:0PC/CHOL (55:45 mol/mol) Mean particle size: 110 nm (100-130 nm) Lipid concentration: 60 mM (60 -65 mM) Internal/External solution: 10% sucrose, 20 mM HEPES, pH 7.0 - 7.5Plain POPC liposomes (100%, 100 nm) Lipid composition: POPC Mean particle size: 100 nm (90-120 nm) Lipid concentration: 60 mM (60 -65 mM) Internal/External solution: 10% sucrose, 20 mM HEPES, pH 7.0-7.5Plain DPPC/CHOL/mPEG2000-DSPE liposomes (100 nm) Lipid composition: DPPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol) Mean particle size: 100 nm (95 - 120 nm) Lipid concentration: 60 mM (60 -65 mM) Internal/External solution: 10% sucrose, 20 mM HEPES, pH 7.0-7.5Preformed Plain DSPC/CHOL/mPEG2000-DSPE liposomes (100 nm) Lipid composition: DSPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol) Mean particle size: 100 nm (95 - 120 nm) Lipid concentration: 60 mM (60 -65 mM) Internal/External solution: 10% sucrose, 20 mM HEPES, pH 7.0-7.5Plain HSPC/CHOL/mPEG2000-DSPE liposomes (100 nm) Lipid composition: HSPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol) Mean particle size: 100 nm (95 - 120 nm) Lipid concentration: 60 mM (60 -65 mM) Internal/External solution: 10% sucrose, 20 mM HEPES, pH 7.0 - 7.5,Plain 20:0PC/CHOL/mPEG2000-DSPE liposomes (110 nm) Lipid composition: 20:0PC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol) Mean particle size: 110 nm (100 - 130 nm) Lipid concentration: 60 mM (60 -65 mM) Internal/External solution: 10% sucrose, 20 mM HEPES, pH 7.0 - 7.52Combo kit of Doxoves and plain control liposomes^https://www.liposomeexpert.com/drug-loaded-liposomes/stealth-liposomal-irinotecan-hcl-2-0mg-ml/jPEGylated Liposomal Topotecan HCl Lipid composition: HSPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol) Lipid concentration: 20.0 mM Topotecan HCl: 2.0 mg/mL Encapsulation efficiency: > 95% Loading battery: 250 mM ammonium sulfate Mean particle size: 100 nm (80-110 nm) External solution: 10% sucrose, 20 Mm HEPES, pH 7.0 Shelf-life: 3 months, storage: 2-8 degree C]https://www.liposomeexpert.com/drug-loaded-liposomes/stealth-liposomal-topotecan-hcl-2-0mg-ml/DMTAP/DOPE Cationic Liposomes Lipid composition: DMTAP/DOPE (50:50 mol/mol) Mean particle size: 80-100 nm Lipid concentration: 5 mM (3.5 mg/mL) Bulk solution: DEPC water, 10% EthanolWhttps://www.liposomeexpert.com/cationic-liposomes/copy-of-cationic-liposomes-dotap-dope/DOTAP/DOPE Cationic Liposomes Lipid composition: DOTAP/DOPE (50:50 mol/mol) Mean particle size: 80-100 nm Lipid concentration: 5 mM (3.61 mg/mL) Bulk solution: DEPC water, 10% EthanolDDAB/DOPE Cationic Liposomes Lipid composition: DDAB/DOPE (50:50 mol/mol) Mean particle size: 80-100 nm Lipid concentration: 5 mM (3.44 mg/mL) Bulk solution: DEPC water, 10vol% ethanolOhttps://www.liposomeexpert.com/products/Cationic-Liposomes-DDAB%7B47%7DDOPE.htmlDC-CHOL/DOPE Cationic Liposomes Lipid composition: DC-CHOL/DOPE (30:70 mol/mol) Mean particle size: 80-100 nm Lipid concentration: 5 mM (3.41 mg/mL) Bulk solution: DEPC water, 10 vol% ethanol Qhttps://www.liposomeexpert.com/cationic-liposomes/cationic-liposomes-dc-chol-dope/DODAP/DOPE Cationic Liposomes Lipid composition: DODAP/DOPE (50:50 mol/mol) Mean particle size: 80-100 nm Lipid concentration: 5 mM (3.48 mg/mL) Bulk solution: DEPC water, 10vol% ethanol Note: DODAP liposomes should be stored at 2-8 degree C at all times and used within one month.Ohttps://www.liposomeexpert.com/cationic-liposomes/cationic-liposomes-dodap-dope/8Placebo Control DOPC/CHOL Liposomes (100nm) Lipid composition: DOPC/CHOL (55:45 mol/mol) Lipid concentration: 50 mM (50-55 mM) Dye: no dye Mean particle size: 100 nm (85-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.5 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopen vialshttps://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/placebo-control-dopc-chol-liposomes-f60103-p/https://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/dopc-chol-liposomes-labeled-with-dansyl-dhpe-f60103< f-d/https://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/dopc-chol-liposomes-labeled-with-fluorescein-dhpe-f60103f-f/Fluorescent DOPC/CHOL Liposomes labeled with Fluorescein DHPE (100nm) Lipid composition: DOPC/CHOL/ Fluorscein -DHPE (54:45:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Fluorscein DHPE: 0.5 mM (0.59 mg/mL) (excitation/emission maxima ~496/519 nm) Mean particle size: 100 nm (80-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.5 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from lightFluorescent DOPC/CHOL Liposomes Labeled with Marina Blue - DHPE (100nm) Lipid composition: DOPC/CHOL/MB-DHPE (54:45:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Marina Blue-DHPE: 0.5 mM (0.50 mg/mL) Ex/Em~365/460 nm Mean particle size: 100 nm (80-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.5 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from lighthttps://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/dopc-chol-liposomes-labeled-with-marina-blue-dhpe-f60103f-mb/Fluorescent DOPC/CHOL Liposomes Labeled with NBD - PE (100nm) Lipid composition: DOPC/CHOL/NBD-PE (54:45:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) NBD - PE: 0.5 mM (0.50 mg/mL) Ex/Em: ~463/536 nm Mean particle size: 100 nm (80-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from lighthttps://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/dopc-chol-liposomes-labeled-with-nbd-pe-f60103f-nbd/Fluorescent DOPC/CHOL Liposomes labeled with Oregon Green 488 DHPE (100nm) Lipid composition: DOPC/CHOL/OG-DHPE (54:45:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Oregon Green 488 DHPE: 0.5 mM (0.54 mg/mL) Ex/Em: ~496/524 nm Mean particle size: 100 nm (85-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from light https://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/dopc-chol-liposomes-labeled-with-oregon-green-488-dhpe-f60103f-og/Fluorescent DOPC/CHOL Liposomes labeled with Rhodamine DHPE (100nm) Lipid composition: DSPC/CHOL/Rh-DHPE (54:45:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Rh-DHPE: 0.5mM (0.67mg/mL) Ex/Em: ~560/580 nm Mean particle size: 100 nm (85-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.5 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from lighthttps://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/dopc-chol-liposomes-labeled-with-rhodamine-dhpe-f60103f-r/Fluorescent DOPC/CHOL Liposomes Labeled withTRITC - DHPE (100nm) Lipid composition: DOPC/CHOL/TC-DHPE (54:45:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) TRITC - DHPE: 0.5 mM (0.62 mg/mL) Ex/Em: ~555/580 nm Mean particle size: 100 nm (80-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.5 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from lighthttps://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/dopc-chol-liposomes-labeled-with-tritc-dhpe-f60103f-tc/Fluorescent DOPC/CHOL Liposomes labeled with Texas Red 488 DHPE (100nm) Lipid composition: DOPC/CHOL/TR-DHPE (54:45:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Texas Red DHPE: 0.5 mM (0.54 mg/mL) Ex/Em: ~595/615 nm Mean particle size: 100 nm (85-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.5 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from lightohttps://www.liposomeexpert.com/fluorescent-liposomes/dopc-chol-liposomes-labeled-with-texas-red-dhpe-f60103f-tr/https://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/dopc-chol-mpeg-dspe-liposomes-labeled-with-dansyl-dhpe-f60203f-d/DOPC/CHOL/mPEG-DSPE Liposomes labeled with Fluorescein DHPE (100nm) Lipid composition: DOPC/CHOL/mPEG2000-DSPE/FITC-DHPE (49:45:5:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Fluorscein DHPE: 0.5mM (0.59 mg/mL) Ex/Em: ~496/519 nm Mean particle size: 100 nm (80-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.5 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from lightFluorescent DOPC/CHOL/mPEG2000-DSPE Liposomes Labeled with Marina Blue - DHPE (100nm) Product code: F60203F-MB Lipid composition: DOPC/CHOL/mPEG2000-DSPE/MB-DHPE (49:45:5:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Marina Blue - DHPE: 0.5 mM (0.50 mg/mL) Ex/Em: ~365/460 nm Mean particle size: 100 nm (80-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from lightFluorescent DOPC/CHOL/mPEG2000-DSPE Liposomes Labeled with NBD - PE (100nm) Product code: F60203F-NBD Lipid composition: DOPC/CHOL/mPEG2000-DSPE/NBD-PE (49:45:5:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) NBD -PE: 0.5 mM (0.50 mg/mL) Ex/Em: ~463/536 nm Mean particle size: 100 nm (80-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from lighthttps://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/dopc-chol-mpeg-dspe-liposomes-labeled-with-nbd-pe-f60203f-nbd/Fluorescent DOPC/CHOL/mPEG-DSPE Liposomes labeled with Oregon Green 488 DHPE (100nm) Lipid composition: DOPC/CHOL/mPEG-2000-DSPE/OG 488-DHPE (49:45:5:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Oregon Green 488 DHPE: 0.5mM (0.54 mg/mL) Ex/Em: ~496/524 nm Mean particle size: 100 nm (85-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from lighthttps://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/dopc-chol-mpeg-dspe-liposomes-labeled-with-oregon-green-488-dhpe-f60203f-og/Fluorescent DOPC/CHOL/mPEG2000-DSPE Liposomes labeled with Rhodamine DHPE (100nm) Lipid composition: DOPC/CHOL/mPEG2000-DSPE/Rh-DHPE (49:45:5:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Rhodamine -DHPE: 0.5 mM (0.67mg/mL) Ex/Em: ~560/580 nm Mean particle size: 100 nm (85-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from lighthttps://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/dopc-chol-mpeg2000-dspe-liposomes-labeled-with-rhodamine-dhpe-f60203f-r/Fluorescent DOPC/CHOL/mPEG2000-DSPE Liposomes Labeled with TRITC - DHPE (100nm) Lipid composition: DOPC/CHOL/mPEG2000-DSPE/TC-DHPE (49:45:5:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) TRITC - DHPE: 0.5 mM (0.62 mg/mL) Ex/Em: ~555/580 nm Mean particle size: 100 nm (80-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from lighthttps://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/dopc-chol-mpeg-dspe-liposomes-labeled-with-tritc-dhpe-f60203f-tc/Fluorescent DOPC/CHOL/mPEG-DSPE Liposomes labeled with Texa Red 488 DHPE (100nm) Lipid composition: DOPC/CHOL/mPEG2000-DSPE/TR-DHPE (49:45:5:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Texas Red DHPE: 0.5mM (0.54 mg/mL) Ex/Em: ~595/615 nm Mean particle size: 100 nm (85-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from lighthttps://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/dopc-chol-mpeg-dspe-liposomes-labeled-with-texas-red-dhpe-f60203f-tr/TPlacebo Control DOPC/CHOL/PEG2000-DSPE Liposomes (100nm) Lipid composition: DSPC/CHOL/PEG2000-DSPE (55:45 mol/mol) Lipid concentration: 50 mM (50-55 mM) Dye: no dye Mean particle size: 100 nm (85-110 nm) Hydration < buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vialshttps://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/placebo-control-dopc-chol-peg-dspe-liposomes-f60203-p/3Plain Control Liposomes for Clophosome-A (Anionic)hhttps://www.liposomeexpert.com/clophosome-clodronate-liposomes/clophosome-a-clodronate-liposomes-anionic/ghttps://www.liposomeexpert.com/clophosome-clodronate-liposomes/combo-clophosome-a-and-control-liposomes/Combo: Clophosome-A and Control Liposomes This kit consists of the following items 1 vial (2 or 10mL) of Clophosome-A - anionic clodronate liposomes (F70101C-A) 1 vial (2 or 10mL) of control anionic liposomes (F70101-A) 2Combo: Clophosome - A, the Fluorescent liposomes and the Control Liposomes This kit consists of the following items 1 vial (2 or 10mL) of Clophosome - clodronate liposomes (F70101C-A) 1 vial (2 or 10mL) of fluorescent control liposomes (F70101F-A) 1 vial (2 or 10mL) of control plain liposomes (F70101-A)ohttps://www.liposomeexpert.com/clophosome-clodronate-liposomes/clophosome-a-fluorescent-plain-control-liposomes/+Clophosome, Clodronate Liposomes (Neutral)fhttps://www.liposomeexpert.com/clophosome-clodronate-liposomes/clophosome-clodronate-liposomes-neutral/bCombo: Clophosome and Clophosome-A And Control Liposomes This all-in-one set is an excellent choice if you want to evaluate and compare the two clodronate liposome products. Included in this kit are one vial of each of the two clodronate liposomes and their plain control liposomes. This kit consists of the following items 1 vial (2 mL or 10 mL) of Clophosome - clodronate liposomes (F70101C-N) 1 vial (2 mL or 10 mL) of Clophosome-A - Anionic clodronate liposomes (F70101C-A) 1 vial (2 mL or 10 mL) of neutral control liposomes (F70101-N) 1 vial (2 mL or 10 mL) of anionic control liposomes (F70101-A)https://www.liposomeexpert.com/clophosome-clodronate-liposomes/all-in-one-combo-kit-clophosome-clophosome-a-and-control-liposomes/Evaluation samples: Clophosome and Clophosome - A This kit consists one of both of the following items 1 vial (1 mL ) of Clophosome - clodronate liposomes (F70101C-N) 1 vial (1 mL ) of Clophosome-A - clodronate liposomes (F70101C-A) You pay for the shipping only\https://www.liposomeexpert.com/clophosome-clodronate-liposomes/evaluation-samples-clophosome/Combo: Clophosome and Control Liposomes Combo (neutral) This kit consists of the following items 1 vial (2 or 10mL) of Clophosome - clodronate liposomes (F70101C-N) 1 vial (2 or 10mL) of control plain liposomes (F70101-N)ehttps://www.liposomeexpert.com/clophosome-clodronate-liposomes/combo-clophosome-and-control-liposomes/1Plain Control Liposomes for Clophosome (Neutral){https://www.liposomeexpert.com/clophosome-clodronate-liposomes/combo-clophosome-fluorescent-plain-control-liposomes-neutral/-Combo: Clophosome and the Fluorescent and Control Liposomes (Neutral) This kit consists of the following items 1 vial (2 or 10mL) of Clophosome - clodronate liposomes (F70101C-N) 1 vial (2 or 10mL) of fluorescent control liposomes (F70101N-F) 1 vial (2 or 10mL) of control plain liposomes (F70101-N)uhttps://www.liposomeexpert.com/clophosome-clodronate-liposomes/fluorescent-control-liposomes-for-clophosome-a-anionic/Fluorescent Control Liposomes for Clophosome (Neutral) The fluorescent control liposomes contain the lipophilic dye Dil incorporated in the bilayers. It has comparable physical and chemical attributes as for the Clophosome except no active is encapsulated inside. It is used for tracking the cellular uptake of the liposomes by common methods like confocal, FACS, etc. Lipid composition: phosphatidylcholine and cholesterol Dye: 0.15 mM (0.14mg/mL) Stability: 6 months for unopened vialsdhttps://www.liposomeexpert.com/clophosome-clodronate-liposomes/fluorescent-control-liposomes-neutral/mhttps://www.liposomeexpert.com/clophosome-clodronate-liposomes/plain-control-liposomes-for-clophosome-neutral/\https://www.liposomeexpert.com/doxoves-liposomal-doxorubicin-hcl/dilution-buffer-for-doxoves/https://www.liposomeexpert.com/pre-formed-liposomes/empty-plain-non-pegylated-liposomes/plain-dppc-chol-liposomes-55-45-mol-mol-100-nm/https://www.liposomeexpert.com/pre-formed-liposomes/empty-plain-non-pegylated-liposomes/plain-dspc-chol-liposomes-55-45-mol-mol-100-nm/https://www.liposomeexpert.com/pre-formed-liposomes/empty-plain-non-pegylated-liposomes/plain-hspc-chol-liposomes-55-45-mol-mol-100-nm/https://www.liposomeexpert.com/pre-formed-liposomes/empty-plain-non-pegylated-liposomes/plain-20-0pc-chol-liposomes-55-45-mol-mol-100-nm/xhttps://www.liposomeexpert.com/pre-formed-liposomes/empty-plain-non-pegylated-liposomes/plain-pure-dopc-liposomes-100-nm/xhttps://www.liposomeexpert.com/pre-formed-liposomes/empty-plain-non-pegylated-liposomes/plain-pure-popc-liposomes-100-nm/https://www.liposomeexpert.com/pre-formed-liposomes/empty-plain-pegylated-liposomes/plain-dppc-chol-mpeg2000-dspe-liposomes-50-45-5-mol-mol-100-nm/https://www.liposomeexpert.com/pre-formed-liposomes/empty-plain-pegylated-liposomes/f10204-plain-hspc-chol-mpeg2000-dspe-liposomes-50-45-5-mol-mol-100-nm/https://www.liposomeexpert.com/pre-formed-liposomes/empty-plain-pegylated-liposomes/plain-20-0pc-chol-mpeg2000-dspe-liposomes-50-45-5-mol-mol-100-nm/https://www.liposomeexpert.com/pre-formed-liposomes/ammonium-gradient-liposomes-for-active-loading/dspc-chol-55-45-mol-mol-liposomes-with-ammonium-sulfate-gradient-100nm/https://www.liposomeexpert.com/pre-formed-liposomes/ammonium-gradient-liposomes-for-active-loading/hspc-chol-55-45-mol-mol-liposomes-with-ammonium-sulfate-gradient-100nm/5DSPC/CHOL (55:45 mol/mol) Liposomes with Ammonium Gradient (100nm) Lipid composition: DSPC/CHOL (55:45 mol/mol) Mean particle size: 100 nm (95 - 120 nm) Lipid concentration: 60 mM (60 - 70 mM) Hydration buffer (loading battery): 250 mM ammonium sulfate External solution: 10% sucrose, 20mM NaPO4, pH 6.5 0.2https://www.liposomeexpert.com/pre-formed-liposomes/ammonium-gradient-liposomes-for-active-loading/f20204a-hspc-chol-mpeg2000-dspe-50-45-5-mol-mol-liposomes-with-ammonium-sulfate-gradient-100nm/https://www.liposomeexpert.com/pre-formed-liposomes/ammonium-gradient-liposomes-for-active-loading/dspc-chol-mpeg-dspe-50-45-5-mol-mol-liposomes-with-ammonium-sulfate-gradient-100nm/https://www.liposomeexpert.com/pre-formed-liposomes/ammonium-gradient-liposomes-for-active-loading/hspc-chol-mpeg2000-dspe-56-2-38-5-5-3-liposomes-with-ammonium-sulfate-gradient-100nm/\DSPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol) Liposomes with Ammonium Sulfate Gradient (100nm) Lipid composition: DSPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol) Mean particle size: 100 nm (95 - 120 nm) Lipid concentration: 60mM (60 - 65 mM) Hydration buffer (loading battery): 250 mM ammonium sulfate External solution: 10% sucrose, 20mM NaPO4, pH 6.5 0.2gPEGylated HSPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol) Liposomes with Ammonium Sulfate Gradient (100nm) Lipid composition: HSPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol) Mean particle size: 100 nm (95 - 120 nm) Lipid concentration: 60 mM(60 - 65 mM) Hydration buffer (loading battery): 250 mM ammonium sulfate External solution: 10% sucrose, 20mM NaPO4, pH 6.5 0.2\HSPC/CHOL/mPEG2000-DSPE (56.2:38.5:5.3) Liposomes with Ammonium Gradient Sulfate (100nm) Lipid composition: HSPC/CHOL/mPEG2000-DSPE (56.2:38.5:5.3 mol/mol) Mean particle size: 100 nm (95 - 120 nm) Lipid concentration: 60 (60 -70mM) Hydration buffer (loading battery): 250 mM ammonium sulfate External solution: 10% sucrose, 20mM NaPO4, pH 6.5 0.2https://www.liposomeexpert.com/pre-formed-liposomes/ammonium-gradient-liposomes-for-active-loading/suv-hspc-chol-mpeg2000-dspe-56-2-38-5-5-3-liposomes-with-ammonium-sulfate-gradient-85-nm/aSUV HSPC/CHOL/mPEG2000-DSPE (56.2/38.5/5.3) Liposomes with Ammonium Sulfate Gradient (85 nm) Lipid composition: HSPC/CHOL/mPEG2000-DSPE (56.2:38.5:5.3 mol/mol) Mean particle size: 85 nm (80 - 90nm) Lipid concentration: 60mM (60 - 70 mM) Hydration buffer (loading battery): 250 mM ammonium sulfate External so< lution: 10% sucrose, 20mM NaPO4, pH 6.5 0.2USACanadaOhttps://www.liposomeexpert.com/cationic-liposomes/cationic-liposomes-dotap-dope/5HSPC/CHOL (55:45 mol/mol) Liposomes with Ammonium Gradient (100nm) Lipid composition: HSPC/CHOL (55:45 mol/mol) Mean particle size: 100 nm (95 - 120 nm) Lipid concentration: 60 mM (60 - 70 mM) Hydration buffer (loading battery): 250 mM ammonium sulfate External solution: 10% sucrose, 20mM NaPO4, pH 6.5 0.2Plain DOPC liposomes (100%, 100 nm) Lipid composition: DOPC Mean particle size: 100 nm (90-120 nm) Lipid concentration: 60 mM (60 -65 mM) Internal/External solution: 10% sucrose, 20 mM HEPES, pH 7.0-7.5Combo Kit of Doxoves And Plain Control Liposomes This combo kit composed of one vial of Doxoves (F30204B-D) and one vial of the plain ammonium sulfate control liposomes (F30204B-C)5Dilution Buffer for Doxoves This buffer dilution is made to match the bulk solution for most liposome encapsulated doxorubicin, Doxoves Composition: 10% sucrose, 10 mM histidine, pH 6.5 0.2 Volume: 50 mL Storage: sterile filtered (0.2祄), store at 2-8 degree C Shelf-life: 6 months stored in refrigerator$DOPC/CHOL Liposomes labeled with DiAzhttps://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/dopc-chol-liposomes-labeled-with-dia/ F60103F-DO-1$DOPC/CHOL Liposomes labeled with DiOzhttps://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/dopc-chol-liposomes-labeled-with-dio/$DOPC/CHOL Liposomes labeled with DiR$DOPC/CHOL Liposomes labeled with DiD6PEGylated DOPC/CHOL/mPEG-PE Liposomes labeled with DiDhttps://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/pegylated-dopc-chol-mpeg-pe-liposomes-labeled-with-did/.PEGylated DOPC/CHOL Liposomes labeled with DiAhttps://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/pegylated-dopc-chol-liposomes-labeled-with-dia/.PEGylated DOPC/CHOL Liposomes labeled with DiIhttps://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/pegylated-dopc-chol-liposomes-labeled-with-dii/.PEGylated DOPC/CHOL Liposomes labeled with DiRhttps://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/pegylated-dopc-chol-liposomes-labeled-with-dir/.PEGylated DOPC/CHOL Liposomes labeled with DiOhttps://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/pegylated-dopc-chol-liposomes-labeled-with-dio/ F30204B-C2-2%Control liposomes for Doxoves (20mM)"Doxoves-Liposomal Doxorubicin HCl~https://www.liposomeexpert.com/doxoves-liposomal-doxorubicin-hcl/f30204b-c2-control-liposomes-for-doxoves-2-0mg-ml-new-product/ F30204B-C2-10 F30204B-D2-28Doxoves - STEALTH Liposomal Doxorubicin HCl (2.0mg/mL) F30204B-D2-10shttps://www.liposomeexpert.com/doxoves-liposomal-doxorubicin-hcl/doxoves-stealth-liposomal-doxorubicin-hcl-4-0mg-ml/https://www.liposomeexpert.com/doxoves-liposomal-doxorubicin-hcl/copy-of-doxoves-pegylated-liposomal-doxorubicin-hspc-chol-mpeg2000-dspe-56-2-38-5-5-3-mol-mol-1/https://www.liposomeexpert.com/doxoves-liposomal-doxorubicin-hcl/copy-of-doxoves-pegylated-liposomal-doxorubicin-hspc-chol-mpeg2000-dspe-56-2-38-5-5-3-mol-mol/ F30204C-D2-2FCombo kit of Doxoves (2.0mg/mL) Control liposomes for Doxoves (20mM)zhttps://www.liposomeexpert.com/doxoves-liposomal-doxorubicin-hcl/combo-kit-of-doxoves-2-0mg-ml-and-plain-control-liposomes/ F30204C-D2-10 F30204B-D-2 F30204B-D-10 F30204C-D-2 F30204C-D-10 F30204B-C-2 F30204B-C-10 F60103F2-P,DOPC/CHOL Liposomes labeled with dansyl DOPEuFluorescent DOPC/CHOL Liposomes Labeled with dansyl - DOPE (100nm) Lipid composition: DOPC/CHOL/Dansyl - DOPE (54:45:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Dansyl DOPE: 0.5 mM (0.50 mg/mL) Mean particle size: 100 nm (80-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.5 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials6DOPC/CHOL/mPEG-DSPE Liposomes Labeled with Dansyl DOPEFluorescent DOPC/CHOL Liposomes Labeled with dansyl - DOPE (100nm) Lipid composition: DOPC/CHOL/mPEG2000-DSPE/Dansyl - DOPE (49:45:5:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Dansyl DOPE: 0.5 mM (0.50 mg/mL) Ex/Em: ~ 336D 517 nm Mean particle size: 100 nm (80-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Stability: 6 month for unopened vials, protect from lightDoxoves - PEGylated Liposomal Doxorubicin HCl (2.0mg/mL) Lipid composition: HSPC/CHOL/mPEG2000-DSPE (56.2:38.5:5.3 mol/mol) Lipid concentration: 20.0 mM Doxorubicin HCl: 2.0 mg/mL Encapsulation efficiency: > 95% (typically 98%) Loading battery: 250 mM ammonium sulfate Mean particle size: 85 nm (80 - 90 nm) External solution: 10% sucrose, 10 mM histidine, pH 6.5 Shelf-life: 6 months, storage: 2-8 degree CPlain Control Liposomes for Doxoves Lipid composition: HSPC/CHOL/mPEG2000-DSPE (56.2:38.5:5.3 mol/mol) Lipid concentration: 20 mM Dox HCl concentration: none Loading battery: 250 mM ammonium sulfate Mean particle size: 85 nm (80-90 nm) External solution: 10% sucrose, 10 mM histidine, pH 6.0 - 6.5 Storage and Stability: stable for 6 months when stored in refrigerator (2-8 degree C)Combo Kit of Doxoves (2.0mg/mL) And The Plain Control Liposomes (20mM) For your convenience, this combo kit composed of one vial of Doxoves (F30204B-D2) and one vial of the plain ammonium sulfate control liposomes (F30204B-C2) at a discount. Plain Control Liposomes for Doxoves Lipid composition: HSPC/CHOL/mPEG2000-DSPE (56.2:38.5:5.3 mol/mol) Lipid concentration: 40 mM Dox HCl concentration: none Loading battery: 250 mM ammonium sulfate Mean particle size: 85 nm (80-90 nm) External solution: 10% sucrose, 10 mM histidine, pH 6.0 - 6.5 Storage and Stability: stable for 6 months when stored in refrigerator (2-8 degree C)Fluorescent DOPC/CHOL Liposomes labeled with Dil (100nm)High quality LUV liposomes labeled with Dil are ready to use. The liposomes are prepared by the extrusion method to 100nm with very tight particle size distribution. The product is sterile filtered and filled in sterile vials guaranteed to be stable for 6 months when stored in refrigerator. Lipid composition: DOPC/CHOL (54:45 mol/mol) Lipid concentration: 50 mM (50-55 mM) DiI: 0.5mM (0.47mg/mL) Mean particle size: 100 nm (90-120 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Shelf-life: 6 months guaranteed for unopened vialsuFluorescent DOPC/CHOL Liposomes labeled with DiA (100nm) High quality LUV liposomes labeled with DiA are ready to use. The liposomes are prepared by the extrusion method to 100nm with very tight particle size distribution. The product is sterile filtered and filled in sterile vials guaranteed to be stable for 6 months when stored in refrigerator. Lipid composition: DOPC/CHOL (54:45 mol/mol) Lipid concentration: 50 mM (50-55 mM) DiA: 0.5mM (0.39mg/mL) Mean particle size: 100 nm (90-120 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Shelf-life: 6 month for unopen vialsFluorescent DOPC/CHOL Liposomes labeled with DiO (100nm) The fluorescent control liposomes contain the green lipophilic dye DiO incorporated in the bilayers. It is used for tracking the cellular uptake of the liposomes by common methods like confocal, FACS, etc. The green fluorescent, lipophilic carbocyanine DiOC18(3) is widely used as a lipophilic tracer. It is weakly fluorescent in water but highly fluorescent and quite photostable when incorporated into membranes. It has an extremely high extinction coefficient and short< excited-state lifetimes (~1 nanosecond) in lipid environments.Lipid composition: DOPC/CHOL (54:45 mol/mol) Lipid concentration: 50 mM (50-55 mM) Mean particle size: 100 nm (90-120 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Dye: 0.5 mM (0.44 mg/mL) Stability: 6 months for unopened vials Storage: 2-8 篊 'DiO'; DiOC18(3) (3,3'-Dioctadecyloxacarbocyanine Perchlorate) (Invitrogen D-275) Ex/Em: 484/501 nmFluorescent DOPC/CHOL Liposomes labeled with DiD (100nm)The fluorescent control liposomes contain the lipophilic dye DiD incorporated in the bilayers. It is used for tracking the cellular uptake of the liposomes by common methods like confocal, FACS, etc. The far-red fluorescent, lipophilic carbocyanine DiD is a longer-wavelength DiI analog. It is an oil at room temperature and weakly fluorescent in water but highly fluorescent and quite photostable when incorporated into membranes. It has an extremely high extinction coefficient and short excited-state lifetimes (~1 nanosecond) in lipid environments. Lipid composition: DOPC/CHOL (54:45 mol/mol) Lipid concentration: 50 mM (50-55 mM) Mean particle size: 100 nm (90-120 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 DiD: 0.5 mM (0.48mg/mL) Stability: 6 months for unopened vials Storage: 2-8 篊 'DiD'; DiIC18(5) oil (1,1'-Dioctadecyl-3,3,3',3'-Tetramethylindodicarbocyanine Perchlorate) (Invitrogen D-307) Ex/Em: 644/665 nm*Fluorescent DOPC/CHOL/mPEG-DSPE Liposomes labeled with DiD (100nm) The fluorescent control liposomes contain the lipophilic dye DiD incorporated in the bilayers. It is used for tracking the cellular uptake of the liposomes by common methods like confocal, FACS, etc. The far-red fluorescent, lipophilic carbocyanine DiD is a longer-wavelength DiI analog. It is an oil at room temperature and weakly fluorescent in water but highly fluorescent and quite photostable when incorporated into membranes. It has an extremely high extinction coefficient and short excited-state lifetimes (~1 nanosecond) in lipid environments. Lipid composition: DOPC/CHOL/mPEG-2000-DSPE (50:45:5 mol/mol) Lipid concentration: 50 mM (50-55 mM) Lipid concentration: 50 mM (50-55 mM) Mean particle size: 100 nm (85-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 DiD: 0.5 mM (0.48mg/mL) Stability: 6 months for unopened vials Storage: 2-8 篊 'DiD'; DiIC18(5) oil (1,1'-Dioctadecyl-3,3,3',3'-Tetramethylindodicarbocyanine Perchlorate) (Invitrogen D-307) Ex/Em: 644/665 nmFluorescent DOPC/CHOL Liposomes labeled with DiA (100nm) High quality LUV liposomes labeled with DiA are ready to use. The liposomes are prepared by the extrusion method to 100nm with very tight particle size distribution. The product is sterile filtered and filled in sterile vials guaranteed to be stable for 6 months when stored in refrigerator. Lipid composition: DOPC/CHOL/mPEG-DSPE (50:45:5 mol/mol) Lipid concentration: 50 mM (50-55 mM) DiA: 0.5mM (0.39mg/mL) Mean particle size: 100 nm (85-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Shelf-life: 6 month for unopen vials 'DiA'; (Invitrogen D-3883) 4-Di-16-ASP (4-(4-(Dihexadecylamino)styryl)-N-Methylpyridinium Iodide) Ex/Em: 456/590 nmFluorescent DOPC/CHOL/mPEG-DSPE Liposomes labeled with Dil (100nm) High quality LUV liposomes labeled with Dil are ready to use. The liposomes are prepared by the extrusion method to 100nm with very tight particle size distribution. The product is sterile filtered and filled in sterile vials guaranteed to be stable for 6 months when stored in refrigerator. Lipid composition: DOPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol) Lipid concentration: 50 mM (50-55 mM) DiI: 0.5mM (0.47mg/mL) Mean particle size: 100 nm (85-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C) Shelf-life: 6 months guaranteed for unopened vials DiI; DiIC18(3) (Invitrogen V22889) is a lipophilic membrane dye. It is weakly fluorescent until incorporated into liposome membranes. This orange red-fluorescent dye, which is spectrally similar to tetramethylrhodamine, is often used as a long-term tracer for neuronal and other cells. Ex/Em: 550nm/570nm3Clophosome, neutral clodronate liposomes, offers highly efficient in vivo macrophage depletion. Clodronate molecules are encapsulated in small MLV liposomes for superior activity, physical and chemical stability, and convenience of use. It is formulated to an exceptionally high clodronate/lipid ratio. Free clodronate is cleaned out and the liposomal clodronate encapsulation efficiency is more than 90%. Clophosome liposomes remain homogenous and suspended even after long term storage in fridge. It is not viscous and easy to inject. It is manufactured sterile for long term shelf-life. The product is suitable for dosing with various routes including intravenous, intraperitoneal, subcutaneous, intranasal, intratracheal and etc. We have achieved 80-90% macrophage depletion in spleen (red pulp macrophages) 24 hours after a single 0.2 mL intravenous injection. A starting dose of 0.15 - 0.2 mL (i.v. or i.p.) for 20-25g animal body weight is recommended for good consistency in macrophage depletion. Optimization is recommended for your specific applications. Active: clodronate disodium. CAS: 22560-50-5, 7 mg/mL Lipid composition: phosphatidylcholine and cholesterol Bulk solution: phosphate buffered saline (20mM sodium phosphate, 0.9% NaCl), pH 7.0-7.5 Shelf-life: 6 months guaranteed for unopened vials, do not freezePlain Control Liposomes for Clophosome (Neutral) This product of empty liposomes are made to match the physical and chemical attributes of Clophosome without the active clodronate encapsulated. It should be used as a negative control for macrophage depletion studies. Lipid composition: phosphatidylcholine and cholesterol Clodronate concentration: None Bulk solution: phosphate buffered saline (20mM sodium phosphate, 0.9% NaCl), pH 7.0-7.5 Storage and Stability: stable for 6 months when stored in refrigerator (2-8 degree C).Clophosome-A- Clodronate Liposomes (Anionic) Clophosome-A, negatively-charged clodronate liposomes, offers superior efficiency of macrophage depletion. Clodronate molecules are encapsulated in LUV liposomes for superior activity, physical and chemical stability, and convenience of use. It is formulated to an exceptionally high clodronate/lipid ratio. Free clodronate is cleaned out and the liposomal encapsulation efficiency of clodronate is more than 90%. Clophosome liposomes remain homogenous even after long term storage in fridge. It is not viscous and easy to inject even with fine needles. It is manufactured sterile for long term shelf-life. The product is suitable for dosing with various routes including intravenous, intraperitoneal, subcutaneous, intranasal, intratracheal and etc. We have achieved > 90% depletion in splenic macrophages (red pulp macrophages) 24 hours after a single 0.2 mL intravenous injection. A starting dose of 0.15-2 mL (i.v. or i.p.) for 20-25g animal body weight is recommended for good consistency in macrophage depletion. Optimization is recommended for specific applications. Product name: < Clophosome-A Active: clodronat disodium. CAS: 22560-50-5, 7 mg/mL Lipid composition: phosphatidylglycerol, phosphatidylcholine and cholesterol Bulk solution: phosphate buffered saline (20mM sodium phosphate, 0.9% NaCl), pH 7.0-7.5 Shelf-life: 6 months for unopened vials, do not freeze+Plain Control Liposomes for Clophosome-A (Anionic) This product of empty liposomes are made to match the physical and chemical attributes of Clophosome-A without the active clodronate encapsulated. It should be used as a negative control for macrophage depletion studies. Lipid composition: phosphatidylcholine, phosphatidylglycerol and cholesterol Clodronate concentration: None Bulk solution: phosphate buffered saline (20mM sodium phosphate, 0.9% NaCl), pH 7.0-7.5 Storage and Stability: stable for 6 months when stored in refrigerator (2-8 degree C)Fluorescent Control Liposomes for Clophosome-A (Anionic) The fluorescent control liposomes contain the lipophilic dye Dil incorporated in the bilayers. It has comparable physical and chemical attributes as for the Clophosome - A except no active is encapsulated inside. It is used for tracking the cellular uptake of the liposomes by common methods like confocal, FACS, etc. Lipid composition: phosphatidylcholine, phosphatidylglycerol and cholesterol Dye: 0.15 mM (0.14mg/mL) Bulk solution: phosphate buffered saline (20mM sodium phosphate, 0.9% NaCl), pH 7.0-7.5 Storage and Stability: stable for 6 months when stored in refrigerator (2-8 degree C)%Control liposomes for Doxoves (40mM) 10 x 1.0mL F90101TH-00:Product type: In vitro cell transfection reagent Applications Plasmid transfection, protein overexpression Technique: Polymer-based nanoparticles Cell type: Established cell lines, primary cells, hard-to-transfect cells, Adherent cells and suspension cells ample type: Plasmid Serum compatibility: Yes Product size: 0.5, 1.0 and 10x1.0 mL Number of transfections Up to 660 in 24-well plates with 1.0mL reagent up to 330 transfections in 6-well plates Shelf-life: 12 months or longer when store refrigerated (2-8癈) Shipping condition: Room temperature)Trans-Hi"! - In vitro Transfection ReagentCPlacebo Control DOPC/CHOL Liposomes (200nm) Lipid composition: DOPC/CHOL (55:45 mol/mol) Lipid concentration: 50 mM (50-55 mM) Dye: no dye Mean particle size: 230 nm (200-250 nm, intensity weighted lognormal per DSL) Particle size distribution: 80-100nm (half-width) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.5 0.2FPlacebo Control DOPC/CHOL Liposomes (200nm) for Fluorescent liposomesFluorescent DOPC/CHOL Liposomes labeled with DiO (100nm) The fluorescent liposomes contain the green lipophilic dye DiO incorporated in the bilayers. It is used for tracking the cellular uptake of the liposomes by common methods like confocal, FACS, etc. The green fluorescent, lipophilic carbocyanine DiOC18(3) is widely used as a lipophilic tracer. It is weakly fluorescent in water but highly fluorescent and quite photostable when incorporated into membranes. It has an extremely high extinction coefficient and short excited-state lifetimes (~1 nanosecond) in lipid environments.Lipid composition: DOPC/CHOL/mPEG2000-DSPE (50:45;5 mol/mol) Lipid concentration: 50 mM (50-55 mM) Mean particle size: 100 nm (85-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Dye: 0.5 mM (0.44 mg/mL) Stability: 6 months for unopened vials Storage: 2-8 篊 'DiO'; DiOC18(3) (3,3'-Dioctadecyloxacarbocyanine Perchlorate) (Invitrogen D-275) Ex/Em: 484/501 nm8Fluorescent DOPC/CHOL/mPEG-DSPE Liposomes labeled with DiR (100nm) The fluorescent liposomes contain the lipophilic Near IR dye DiR incorporated in the bilayers. It is used for tracking the cellular uptake of the liposomes in vitro and in vivo by common methods like confocal, FACS, NIR imaging etc. The near IR fluorescent, lipophilic carbocyanine DiOC18(7) ("DiR") is weakly fluorescent in water but highly fluorescent and quite photostable when incorporated into membranes. The sulfonate groups incorporated into this DiI analog improves water solubility. It has an extremely high extinction coefficient and short excited-state lifetimes (~1 nanosecond) in lipid environments. Lipid composition: DOPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol) Lipid concentration: 50 mM (50-55 mM) Mean particle size: 100 nm (85-110 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 DiR: 0.5 mM (0.51mg/mL) Stability: 6 months for unopened vials Storage: 2-8 篊 'DiR'; (Invitrogen D-12731) DiIC18(7) (1,1'-Dioctadecyl-3,3,3',3'-Tetramethylindotricarbocyanine Iodide) Ex/Em: 750/780 nmFluorescent DOPC/CHOL Liposomes labeled with DiR (100nm) The fluorescent liposomes contain the lipophilic Near IR dye DiR incorporated in the bilayers. It is used for tracking the cellular uptake of the liposomes in vitro and in vivo by common methods like confocal, FACS, NIR imaging etc. The near IR fluorescent, lipophilic carbocyanine DiOC18(7) ("DiR") is weakly fluorescent in water but highly fluorescent and quite photostable when incorporated into membranes. The sulfonate groups incorporated into this DiI analog improves water solubility. It has an extremely high extinction coefficient and short excited-state lifetimes (~1 nanosecond) in lipid environments. Lipid composition: DOPC/CHOL (54:45 mol/mol) Lipid concentration: 50 mM (50-55 mM) Mean particle size: 100 nm (90-120 nm) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 DiR: 0.5 mM (0.51mg/mL) Stability: 6 months for unopened vials Storage: 2-8 篊 'DiR'; (Invitrogen D-12731) DiIC18(7) (1,1'-Dioctadecyl-3,3,3',3'-Tetramethylindotricarbocyanine Iodide) Ex/Em: 750/780 nm InternationalProduct type: In vitro cell transfection reagent Applications Plasmid transfection, protein overexpression Technique: Polymer-based nanoparticles Cell type: Established cell lines, primary cells, hard-to-transfect cells, Adherent cells and suspension cells ample type: Plasmid Serum compatibility: Yes Product size: 50uL Shelf-life: 12 months or longer when store refrigerated (2-8癈) Shipping condition: Room temperatureInternational, $50 F60103F2-FFluorescent DOPC/CHOL Liposomes labeled with Fluorescein DHPE (200nm) High quality LUV liposomes labeled with fluorescein DHPE are ready to use. The liposomes are prepared by the extrusion technology to 200-250nm nm with tight particle size distribution. The product is semisterile filtered through 0.45um filters and filled in autoclaved vials guaranteed to be stable for 3 months stored in refrigerator. The phospholipid, fluorescein DHPE is labeled on the head group with the green-fluorescent pH-sensitive fluorophore, fluorescein (excitation/emission maxima ~496/519 nm). Lipid composition: DOPC/CHOL/Fluorescein-DHPE (54:45:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Fluorscein DHPE: 0.5 mM (0.59 mg/mL) Mean particle size: 230 nm (200-250 nm, intensity weighted lognormal per DSL) Particle size distribution: 80-100nm (half-width) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.5 0.2 Storage: in refrigerator (2 - 8 degree C) Shelf-life: 3 month for unopened vials, protect from lightFluorescent DOPC/CHOL Liposomes labeled with Rhodamine DHPE (200nm)High quality LUV liposomes labeled with Rhodamine DHPE (Rh-DHPE) are ready to use. The liposomes are prepared by extrusion to 200-250nm with tight particle size distribution. The product is sterile filtered through 0.45um filters and filled in sterile vials guaranteed for 3 months shelf-life properly stored in refrigerator. Rh--DHPE is a phospholipid labeled on the head group with the red-fluorescent rhodamine B fluorophore with excitation/emission maxima ~560/580 nm. For more information on the dye, see Invitrogen L-1392. SpecificationsProduct code: F60103F2-RLipid composition: DOPC/CHOL/Rh-DHPE (54:45:1 mol/mol)Lipid concentration: 50 mM (50-55 mM)Rh-DHPE: 0.5mM (0.67mg/mL)Mean particle size: 230 nm (200-250 nm, intensity weighted lognormal per DSL)Particle size distribution: 80-100nm (half-width)Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.5 0.2Storage: in refrigerator (2 - 8 degree C< )Shelf-life: 3 month for unopened vials, protect from light{https://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/dopc-chol-liposomes-labeled-with-dii/ {https://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/dopc-chol-liposomes-labeled-with-dir/ {https://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/dopc-chol-liposomes-labeled-with-did/ https://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/dopc-chol-mpeg-dspe-liposomes-labeled-with-fluorescein-dhpe-f60203f-f/ https://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/dopc-chol-mpeg-dspe-liposomes-labeled-with-marina-blue-dhpe-f60203f-mb/ https://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/200nm-dopc-chol-liposomes-labeled-with-rhodamine-dhpe-f60103f2-r/ F60103F2-RCFluorescent DOPC/CHOL Liposomes labeled with Rhodamine DHPE (200nm)https://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/200nm-non-fluorescent-dopc-chol-liposomes-f60103f2-p/ F60103F2-TRHFluorescent DOPC/CHOL Liposomes labeled with Texas Red 488 DHPE (200nm)-Fluorescent DOPC/CHOL Liposomes labeled with Texas Red 488 DHPE (200nm) High quality LUV liposomes labeled with Texas Red DHPE (TR-DHPE) are ready to use. The liposomes are prepared by the extrusion technology to 200-250nm with very tight particle size distribution. The product is sterile filtered through 0.45um and filled in sterile vials guaranteed to be stable for 3 months when stored in refrigerator. The phospholipid, Texas Red 1,2-dihexadecanoyl-sn-glycero-3-phosphoethanolamine, triethylammonium salt (Texas Red DHPE) is labeled on the head group with the bright, red-fluorescent Texas Red dye (excitation/emission maxima ~595/615 nm). Lipid composition: DOPC/CHOL/TR-DHPE (54:45:1 mol/mol) Lipid concentration: 50 mM (50-55 mM) Texas Red DHPE: 0.5 mM (0.54 mg/mL) Mean particle size: 230 nm (200-250 nm, intensity weighted lognormal per DSL) Particle size distribution: 80-100nm (half-width) Hydration buffer: 10% sucrose, 20mM HEPES, pH 7.3 0.2 Storage: in refrigerator (2 - 8 degree C)Shelf-life: 3 month for unopened vials, protect from lighthttps://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/200nm-fluorescent-liposomes/200nm-dopc-chol-liposomes-labeled-with-texas-red-dhpe-f60103f2-tr/&Polycarbonate Membrane Filter (19mm, 0.05um) This polycarbonate Track Etch (PCTE) membrane is ideally suited for use as the last extrusion membrane for making 75-85 nm liposomes. Pore size (um): 0.05 Size (mm): 19 Pack Size: 100 Color: white transluscent Thickness: 25um Minimum order: 5 boxesF1N5119,Polycarbonate Membrane Filter (19mm, 0.05um)https://www.liposomeexpert.com/liposome-supplies/extrusion-membranes/19-mm-extrusion-membranes/polycarbonate-membrane-filter-19mm-0-05um/,Polycarbonate Membrane Filter (19mm, 0.08um) F1N8119Polycarbonate Membrane Filter (19mm, 0.08um) This polycarbonate Track Etch (PCTE) membrane is ideally suited for use as the last extrusion membrane for making 80nm liposomes. Pore size (um): 0.08 Size (mm): 19 Pack Size: 100 Color: white transluscent Min order: 5https://www.liposomeexpert.com/liposome-lab-supplies/extrusion-membranes/19-mm-extrusion-membranes/polycarbonate-membrane-filter-19mm-0-08um/+Polycarbonate Membrane Filter (19mm, 0.1um)F1N10119 Polycarbonate Membrane Filter (19mm, 0.1um) This polycarbonate Track Etch (PCTE) membrane is ideally suited for use as the last extrusion membrane for making 100-120 nm liposomes. Pore size (um): 0.1 Size (mm): 19 Pack Size: 100 Color: white transluscent Min order: 5https://www.liposomeexpert.com/liposome-lab-supplies/extrusion-membranes/19-mm-extrusion-membranes/polycarbonate-membrane-filter-19mm-0-1um/+Polycarbonate Membrane Filter (19mm, 0.2um)F1N20119HPolycarbonate Membrane Filter (19mm, 0.2um) This polycarbonate Track Etch (PCTE) membrane is ideally suited for use as the last extrusion membrane for making 200 nm liposomes or as an intermadiate membrane in a step-wise extrusion process. Pore size (um): 0.2 Size (mm): 19 Pack Size: 100 Color: white transluscent Min order: 5https://www.liposomeexpert.com/liposome-lab-supplies/extrusion-membranes/19-mm-extrusion-membranes/polycarbonate-membrane-filter-19mm-0-2um/19mm Extrusion membranesF1N40119+Polycarbonate Membrane Filter (25mm, 0.4um)HPolycarbonate Membrane Filter (25mm, 0.4um) This polycarbonate Track Etch (PCTE) membrane is ideally suited for use as the last extrusion membrane for making 400 nm liposomes or as an intermadiate membrane in a step-wise extrusion process. Pore size (um): 0.4 Size (mm): 19 Pack Size: 100 Color: white transluscent Min order: 5https://www.liposomeexpert.com/liposome-lab-supplies/extrusion-membranes/19-mm-extrusion-membranes/polycarbonate-membrane-filter-19mm-0-4um/,Polycarbonate Membrane Filter (19mm, 1.0 um)F1M10119Polycarbonate Membrane Filter (19mm, 1.0 um) This polycarbonate Track Etch (PCTE) membrane is ideally suited for use as the fisrt membrane in a step-wise extrusion process. Pore size (um): 1.0 Size (mm): 19 Pack Size: 100 Color: white transluscent Min order: 5https://www.liposomeexpert.com/liposome-lab-supplies/extrusion-membranes/19-mm-extrusion-membranes/polycarbonate-membrane-filter-19mm-1-0-um/F1N8125,Polycarbonate Membrane Filter (25mm, 0.08um)25mm Extrusion membraneshttps://www.liposomeexpert.com/liposome-lab-supplies/extrusion-membranes/25mm-extrusion-membranes/polycarbonate-membrane-filter-25mm-0-08um/+Polycarbonate Membrane Filter (25mm, 0.1um)F1N10125 Polycarbonate Membrane Filter (25mm, 0.1um) This polycarbonate Track Etch (PCTE) membrane is ideally suited for use as the last extrusion membrane for making 100-120 nm liposomes. Pore size (um): 0.1 Size (mm): 25 Pack Size: 100 Color: white transluscent Min order: 5 Polycarbonate Membrane Filter (25mm, 0.08um) This polycarbonate Track Etch (PCTE) membrane is ideally suited for use as the last extrusion membrane for making 80-90nm liposomes. Pore size (um): 0.08 Size (mm): 25 Pack Size: 100 Color: white transluscent Min order: 5+Polycarbonate Membrane Filter (25mm, 0.2um)F1N20125HPolycarbonate Membrane Filter (25mm, 0.2um) This polycarbonate Track Etch (PCTE) membrane is ideally suited for use as the last extrusion membrane for making 200 nm liposomes or as an intermadiate membrane in a step-wise extrusion process. Pore size (um): 0.2 Size (mm): 25 Pack Size: 100 Color: white transluscent Min order: 1https://www.liposomeexpert.com/liposome-lab-supplies/extrusion-membranes/25mm-extrusion-membranes/polycarbonate-membrane-filter-25mm-0-2um/https://www.liposomeexpert.com/liposome-lab-supplies/extrusion-membranes/25mm-extrusion-membranes/polycarbonate-membrane-filter-25mm-0-1um/19mm, Extrusion membranesF1N5125,Polycarbonate Membrane Filter (25mm, 0.05um)https://www.liposomeexpert.com/liposome-lab-supplies/extrusion-membranes/25mm-extrusion-membranes/polycarbonate-membrane-filter-25mm-0-05um/ Polycarbonate Membrane Filter (25mm, 0.05um) This polycarbonate Track Etch (PCTE) membrane is ideally suited for use as the last extrusion membrane for making 75-90 nm liposomes. Pore size (um): 0.05 Size (mm): 25 Pack Size: 100 Color: white transluscent Min order: 1F1N40125HPolycarbonate Membrane Filter (25mm, 0.4um) This polycarbonate Track Etch (PCTE) membrane is ideally suited for use as the last extrusion membrane for making 400 nm liposomes or as an intermadiate membrane in a step-wise extrusion process. Pore size (um): 0.4 Size (mm): 25 Pack Size: 100 Color: white transluscent Min order: 1F1M10125,Polycarbonate Membrane Filter (25mm, 1.0 um)Polycarbonate Membrane Filter (25mm, 1.0 um) This polycarbonate Track Etch (PCTE) membrane is ideally suited for use as the fisrt membrane in a step-wise extrusion process. Pore size (um): 1.0 Size (mm): 25 Pack Size: 100 Color: white transluscent Min order: 1https://www.liposomeexpert.com/liposome-lab-supplies/extrusion-membranes/25mm-extrusion-membranes/polyc<arbonate-membrane-filter-25mm-1-0-um/https://www.liposomeexpert.com/liposome-lab-supplies/extrusion-membranes/25mm-extrusion-membranes/polycarbonate-membrane-filter-25mm-0-4um/Transfection Reagentskhttps://www.liposomeexpert.com/trans-hi-dna-transfection-reagent-new/trans-hi-in-vitro-transfection-reagent/thttps://www.liposomeexpert.com/trans-hi-dna-transfection-reagent-new/trans-hi-transfection-reagent-evaluation-sample/newJHigh Potency Clophosome- Clodronate Liposomes (Neutral, 1.0 mL, 20 mg/mL) F70101C-NH tHigh Potency Clophosome- Clodronate Liposomes (Neutral, 1.0 mL, 20 mg/mL) High potency Clophosome is created to satisfy the demand for small volume dosing of concentrated clodronate liposomes through routes that are not amendable for large volume injection, such as intratracheal or intranasal, ICV, or intra-tumor injection. Please note this product has not been fully evaluated for any dosing approaches. Customers are strongly recommended to conduct their own studies to determine the appropriate dose regimen for their experiments. Active: clodronate disodium. CAS: 22560-50-5 Clodronate disodium: 20 mg/mL Volume: 1.0mLhttps://www.liposomeexpert.com/clophosome-clodronate-liposomes/new-product-clophosome-high-potency-clodronate-liposomes-neutral-20mg-ml/"Clophosome - Clodronate LiposomesFluorescent LiposomesCationic Liposomes"Pre-formed Liposomes Empty (Plain).Ammonium Gradient Liposomes for Active Loadingohttps://www.liposomeexpert.com/clophosome-clodronate-liposomes/plain-control-liposomes-for-clophosome-a-anionic/H free evaluation sample, Trans-Hi"! - In vitro Transfection Reagent (50l)EFUSA, $20 Canada, $302017 Cost Effective Date:2017 Cost Expiration Date: F90101TH-05 F90101TH-10 F90101TH-101 F30204-IT-2 F30204-TT-2 F70101C-N-10 F70101C-N-2 F70101-N-2 F70101-N-10 F70101F-N-2 F70101F-N-10 F70101C-NC-2 F70101C-NC-10 F70101C-NF-2 F70101C-NF-10 F70101C-A-2 F70101C-A-10pDoxoves - PEGylated Liposomal Doxorubicin HCl Doxorubicin HCl is loaded into PEGylated liposomes composed of HSPC/CHOL/mPEG2000-DSPE (56.2:38.5:5.3 mol/mol) with ammonium gradient by the active loading approach. It is comparable to the commercial product DOXIL. Lipid composition: HSPC/CHOL/mPEG2000-DSPE (56.2:38.5:5.3 mol/mol) Lipid concentration: 40.0 mM Doxorubicin HCl: 4.0 mg/mL Encapsulation efficiency: > 95% (typically 98%) Loading battery: 250 mM ammonium sulfate Mean particle size: 85 nm (80 - 90 nm) External solution: 10% sucrose, 10 mM histidine, pH 6.5 Shelf-life: 6 months, storage: 2-8 degree C}PEGylated Liposomal Irinotecan HCl Lipid composition: HSPC/CHOL/mPEG2000-DSPE (50:45:5 mol/mol) Lipid concentration: 20.0 mM Iroinotecan HCl: 2.0 mg/mL Encapsulation efficiency: > 95% (typically 98%) Loading battery: 250 mM ammonium sulfate Mean particle size: 100 nm (80-110 nm) External solution: 10% sucrose, 20 mM HEPES, pH 7.0 Shelf-life: 3 months, storage: 2-8 degree CDiscount PriceDiscount F70101-A-2 F70101-A-10 F70101F-A-2 F70101F-A-10 F70101C-NA-2 F70101C-NA-10 F70101C-AC-2 F70101C-AC-10 F70101C-AF-2 F70101C-AF-10F60103-P F60103F-D F60103F-F F60103F-MB F60103F-NBD F60103F-OG F60103F-R F60103F-TC F60103F-TR F60103F-DI F60103F-DA F60103F-DR F60103F-DDhttps://www.liposomeexpert.com/fluorescent-liposomes/fluorescent-liposomes-lipid-dyes/200nm-dopc-chol-liposomes-labeled-with-fluorescein-dhpe-f60103f2-f/EFluorescent DOPC/CHOL Liposomes labeled with Fluorescein DHPE (200nm) F60203F-DO F60203F-DA F60203F-DI F60203F-DR F60203F-DD7 58xB9P:;E=0>sJ?朄緼 錌( 訢 絁餚3朥^$莊)pHyD}?搩 to驆4/}TZ1J! 廿 L#7逖鍺d狆/瘊[{ d Y  vMHw;e B# %%l % %E /'vccB g2蓘  v/tLoq苸  d褚MbP?_*+%&ffffff?'ffffff?(?)?MSamsung CLX-3180 homeC odXXLetterGIS4DINU"`鞢 `SMTJP{C3C1C11A-85F2-4713-B177-286BC89A859A}InputBinAUTORESDLLUniresDLLOrientationPORTRAITCollateOFFMediaTypePrinterDefaultJobBlackOptimizationONResolutiondpi_1200x600x1PaperSizeLETTERPagesPerSheet1PageOrderFrontToBackPageBorderOFFColorModeColorV4DM"dXX333333?333333?&<3U} G}  B} U)C}  G} G} 8G} :B} C} q*D} .B} BvP@8L8L8L8LFtFFlF @F hF hF @ @@@ P@ t @@ @ p@ @ p@ X < < x@ @ @ @ t@ @ @B BJKK  TT  TTUV M\~ N掬@  TT  TTUV M]~ N 錊  TT  TTUV Kr~ O?  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