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RNA甲基化 P-9003

發布時間：2018/7/3點擊次數：908

美國Epigentek集團公司是先進的表觀遺傳(chuan) 學相關(guan) 研究的技術創新者和產(chan) 品開發供應商。公司開發了700多個(ge) 產(chan) 品，為(wei) 表觀遺傳(chuan) 學方麵的研究和新藥研發提供全麵係統的解決(jue) 方案。相比普通方法的產(chan) 品而言，這些*的產(chan) 品在科研分析過程中更簡單、更快捷、更方便、更有效。*的備受推崇的學者、先進的製藥企業(ye) 以及先進的生物技術公司都在使用Epigentek產(chan) 品。讓客戶滿意和幫助客戶在試驗中取得成功是我們(men) 進行技術創新的首要任務。

在EpiGentek全套RNA甲基化產(chan) 品的幫助下，擴展您對RNA甲基化的理解。從(cong) 直接量化“第五RNA堿基”N6-甲基腺苷（m6A）到測量5-mC RNA等，我們(men) 的試劑盒使您可以輕鬆確定RNA甲基化如何影響您的研究項目。

 

m6A RNA甲基化

研究N6-甲基腺苷（m6A） - 真核生物中存在的RNA分子中常見和豐(feng) 富的甲基化修飾。被稱為(wei) “第五RNA堿基”的m6A RNA修飾是可逆的，高度動態的，並且可能發揮與(yu) 甲基化和組蛋白修飾相當的重要生物學作用。

  • EpiQuik m6A RNA甲基化定量試劑盒（比色法） 
    用於以類似ELISA的形式對RNA中的N6-甲基腺苷進行基於吸光度的定量分析

*也適用於(yu)

  • EpiQuik m6A RNA甲基化定量試劑盒（熒光） 
    用於以類似ELISA的形式對RNA中的N6-甲基腺苷進行基於熒光的定量分析

 

  • MethylFlash尿液N6-甲基腺苷（m6A）定量試劑盒（比色法） 
    用於以類似ELISA的形式從尿樣中提取RNA中N6-甲基腺苷的吸光度定量

 

  • 表觀活性酶m6A脫甲基酶活性/抑製測定試劑盒（比色法）
    用於使用核提取物或純化的m6A去甲基化酶對總m6A去甲基化酶活性/抑製的吸光度測量

 

 

5-mC RNA甲基化

研究RNA中5-甲基胞嘧啶（5-mC）的發生 - 一種*的甲基化修飾，發現於(yu) 各種RNA分子中，包括tRNA，rRNA，mRNA和非編碼RNA（ncRNA）。有證據表明RNA胞嘧啶甲基化影響各種生物過程的調節，如RNA穩定性和mRNA翻譯，並且穹窿體(ti) RNA中5-mC的丟(diu) 失可能導致異常加工成可與(yu) microRNA起作用的Argonaute相關(guan) 的小RNA片段。

  • MethylFlash 5-mC RNA甲基化ELISA Easy Kit（熒光） 
    用於以類似ELISA的形式進行基於熒光的全局5-mC RNA甲基化定量

 

  • EpiNext 5-mC RNA Bisulfite-Seq Easy Kit（Illumina） 
    用於RNA亞硫酸氫鹽轉化，然後是“後亞硫酸氫鹽”文庫製備過程

 

  • Methylamp RNA亞硫酸 氫鹽轉化試劑盒
    用於穩定的，基於化學的亞硫酸氫鹽處理RNA，用於甲基化胞嘧啶分析

 


 使用MethylFlash™5-mC RNA甲基化ELISA Easy Kit（熒光）定量來自不同物種的各種RNA樣品的5-mC含量。結果與(yu) MS-LC獲得的結果密切相關(guan) 。

 


 在不同樣品中定量m6A RNA甲基化。將從(cong) 不同組織或細胞分離的200ng RNA加入測定孔中，並使用EpiQuik TM m6A RNA甲基化定量試劑盒測量RNA中含有的m6A。

 

 

RNA甲基化

RNA甲基化是RNA的可逆翻譯後修飾，其表觀遺傳(chuan) 地影響許多生物過程。它發生在不同的RNA中，包括tRNA，rRNA，mRNA，tmRNA，snRNA，snoRNA，miRNA和病毒RNA。通過各種RNA-甲基轉移酶將不同的催化策略用於(yu) RNA甲基化。

N6甲基腺苷（M 6 A）是在存在於(yu) 真核生物的RNA分子中常見的和豐(feng) 富的甲基化修飾和占所有RNA甲基化的80％以上。它可以被稱為(wei) “第五RNA堿基”並且在調節胚胎發育和細胞命運中具有廣泛的作用。特別地，由於(yu) m 6的富集，該RNA修飾被認為(wei) 對於(yu) mRNA調節是重要的A為(wei) 3'UTR。它還與(yu) 包括白血病，乳腺癌和前列腺癌在內(nei) 的癌症有關(guan) 。


N6-甲基腺苷（m 6 A）

5-甲基胞嘧啶（5-mC）是一種表觀遺傳(chuan) 標記，也常見於(yu) 各種RNA分子中。研究人員能夠進行亞(ya) 硫酸氫鹽轉化RNA，進行RT-PCR擴增，克隆和測序，以獲得有關(guan) RNA胞嘧啶甲基化狀態的信息。通過用亞(ya) 硫酸氫鹽處理RNA，將胞嘧啶殘基脫氨基成尿嘧啶，同時保留5-甲基胞嘧啶。

近的數據強烈暗示m 6A和5-mC RNA甲基化影響各種生物過程的調節，例如RNA穩定性和mRNA翻譯，並且異常RNA甲基化有助於(yu) 人類疾病的病因學。此外，穹窿體(ti) RNA中5-mC的損失導致異常加工成Argonaute相關(guan) 的小RNA片段，其可以作為(wei) microRNA起作用。研究人員繼續研究RNA中的m6A和5-mC，以揭示RNA甲基化的奧秘。

圖片

描述

貓。沒有。

尺寸

價(jia) 錢

 

Methylamp RNA亞(ya) 硫酸氫鹽轉化試劑盒
用於(yu) 穩定的，基於(yu) 化學的亞(ya) 硫酸氫鹽處理RNA，用於(yu) 甲基化胞嘧啶分析

輸入類型：

RNA

研究領域：

RNA甲基化

目標應用：

樣本修改

船隻格式：

列/管

 

P-9003-050

50次反應

 

研究工具包

EpiQuik m6A RNA甲基化定量試劑盒（比色法）
用於(yu) 以類似ELISA的形式對RNA中N6-甲基腺苷進行基於(yu) 吸光度的定量
Citations（22） |（5）

輸入類型：

RNA

研究領域：

RNA甲基化

目標應用：

金額定量

船隻格式：

96孔板

 

P-9005-48

48次反應

P-9005-96

96個(ge) 反應

 

 

EpiNext 5-mC RNA Bisulfite-Seq Easy Kit（Illumina）
用於(yu) 精簡RNA亞(ya) 硫酸氫鹽轉化和NGS文庫製備5-甲基胞嘧啶RNA-seq

輸入類型：

RNA

研究領域：

RNA甲基化

目標應用：

金額定量

船隻格式：

96孔板

 

P-9007-12

12個(ge) 反應

P-9007-24

24個(ge) 反應

研究工具包

EpiQuik m6A RNA甲基化定量試劑盒（熒光）

輸入類型：

RNA

研究領域：

RNA甲基化

目標應用：

金額定量

船隻格式：

96孔板

 

P-9008-48

48次測定

P-9008-96

96測定

研究工具包

MethylFlash 5-mC RNA甲基化ELISA Easy Kit（熒光）
用於(yu) 基於(yu) 熒光的定量5-mC RNA甲基化的ELISA樣式
Citations（2）

輸入類型：

RNA

研究領域：

RNA甲基化

目標應用：

金額定量

船隻格式：

96孔板

 

P-9009-48

48次反應

P-9009-96

96個(ge) 反應

研究工具包

表觀活性酶m6A脫甲基酶活性/抑製試劑盒（比色法）

輸入類型：

核提取物或純化酶

研究領域：

RNA甲基化

目標應用：

金額定量

船隻格式：

96孔板

 

P-9013-48

48次測定

P-9013-96

96測定

研究工具包

MethylFlash尿液N6-甲基腺苷（m6A）定量試劑盒（比色）

輸入類型：

尿

研究領域：

RNA甲基化

目標應用：

金額定量

船隻格式：

96孔板

 

P-9015-48

48次測定

P-9015-96

96測定

 

 

輸入類型：

RNA

研究領域：

RNA甲基化

目標應用：

樣本修改

船隻格式：

列/管

100％保證：

6個(ge) 月

目錄號

尺寸

 

P-9003-050

50次反應

 

所述Methylamp™RNA重亞(ya) 硫酸鹽轉化試劑盒是一套完整的用於(yu) 對RNA樣品快速重亞(ya) 硫酸鹽轉化需要優(you) 化試劑。用Methylamp RNA Bisulfite Conversion Kit獲得的轉化RNA適用於(yu) 各種下遊RNA甲基化分析，包括甲基化特異性RT-PCR，MS-HRM和亞(ya) 硫酸氫鹽RNA測序（例如，焦磷酸測序和深度測序）。該套件具有以下特點和優(you) 點：

  • 快速方便的協議，可在3小時內完成。 
  • 當使用範圍的輸入樣品RNA時，將未甲基化的RNA胞嘧啶*轉化為尿嘧啶（> 99.9％），甲基胞嘧啶不能或可忽略不計/錯誤轉化為胸腺嘧啶（<0.1％）。
  • 有效防止RNA降解，防止超過90％的RNA丟失。
  • 包含的對照引物對亞硫酸氫鹽轉化的RNA具有特異性，可用於測試是否已正確實現亞硫酸氫鹽轉化。
  • 少量輸入RNA可用於亞硫酸氫鹽轉化，每次反應低至5 ng。
  • 簡單，可靠，一致的反應條件。

背景信息
中的5-甲基胞嘧啶（5-mC）已被充分研究，並且通常與(yu) 基因表達的抑製有關(guan) ，但也已觀察到在人類中，5-mC發生在各種RNA分子中，包括tRNA，rRNA，mRNA和非編碼RNA（ncRNA）。在mRNA和ncRNA中發現至少10,275個(ge) 5-mC候選位點，其覆蓋了轉錄組中總胞嘧啶殘基的10.6％。5-mC似乎在某些類型的ncRNA中富集，但mRNA相對耗盡。然而，他們(men) 的候選位點的大多數（83％）是在mRNA中發現的。在這些轉錄物中，5-mC似乎在蛋白質編碼序列中被耗盡，但在5'和3'UTR中富集。已知兩(liang) 種不同的甲基轉移酶NSUN2和DNMT2催化真核RNA中的5-mC修飾。近的數據強烈表明RNA胞嘧啶甲基化影響各種生物過程的調節，例如RNA穩定性和mRNA翻譯。此外，穹窿體(ti) RNA中5-mC的損失導致異常加工成Argonaute相關(guan) 的小RNA片段，其可以作為(wei) microRNA起作用。因此，穹窿體(ti) ncRNA的加工受損可能有助於(yu) 與(yu) NSUN2缺乏的人類疾病相關(guan) 的人類疾病的病因學。RNA的亞(ya) 硫酸氫鹽轉化，然後進行RT-PCR擴增，克隆和測序，得到關(guan) 於(yu) RNA胞嘧啶甲基化狀態的可靠信息。通過用亞(ya) 硫酸氫鹽處理RNA，胞嘧啶殘基被脫氨基成尿嘧啶，同時保留5-甲基胞嘧啶完整：穹窿體(ti) RNA中5-mC的丟(diu) 失導致異常加工成Argonaute相關(guan) 的小RNA片段，其可以作為(wei) microRNA起作用。因此，穹窿體(ti) ncRNA的加工受損可能有助於(yu) 與(yu) NSUN2缺乏的人類疾病相關(guan) 的人類疾病的病因學。RNA的亞(ya) 硫酸氫鹽轉化，然後進行RT-PCR擴增，克隆和測序，得到關(guan) 於(yu) RNA胞嘧啶甲基化狀態的可靠信息。通過用亞(ya) 硫酸氫鹽處理RNA，胞嘧啶殘基被脫氨基成尿嘧啶，同時保留5-甲基胞嘧啶完整：穹窿體(ti) RNA中5-mC的丟(diu) 失導致異常加工成Argonaute相關(guan) 的小RNA片段，其可以作為(wei) microRNA起作用。因此，穹窿體(ti) ncRNA的加工受損可能有助於(yu) 與(yu) NSUN2缺乏的人類疾病相關(guan) 的人類疾病的病因學。RNA的亞(ya) 硫酸氫鹽轉化，然後進行RT-PCR擴增，克隆和測序，得到關(guan) 於(yu) RNA胞嘧啶甲基化狀態的可靠信息。通過用亞(ya) 硫酸氫鹽處理RNA，胞嘧啶殘基被脫氨基成尿嘧啶，同時保留5-甲基胞嘧啶完整：和測序產(chan) 生關(guan) 於(yu) RNA胞嘧啶甲基化狀態的可靠信息。通過用亞(ya) 硫酸氫鹽處理RNA，胞嘧啶殘基被脫氨基成尿嘧啶，同時保留5-甲基胞嘧啶完整：和測序產(chan) 生關(guan) 於(yu) RNA胞嘧啶甲基化狀態的可靠信息。通過用亞(ya) 硫酸氫鹽處理RNA，胞嘧啶殘基被脫氨基成尿嘧啶，同時保留5-甲基胞嘧啶完整：

圖2.   RNA的亞(ya) 硫酸氫鹽轉化，然後進行RT-PCR擴增，克隆和測序，得到關(guan) 於(yu) RNA胞嘧啶甲基化狀態的可靠信息。通過用亞(ya) 硫酸氫鹽處理RNA，將胞嘧啶殘基脫氨基成尿嘧啶，同時保留5-甲基胞嘧啶。

圖3.   RNA亞(ya) 硫酸氫鹽測序分析。從(cong) MCF-7細胞分離的RNA在使用對亞(ya) 硫酸氫鹽轉化的RNA特異的28S核糖體(ti) RNA引物進行PCR擴增後進行亞(ya) 硫酸氫鹽處理，c合成和測序。未甲基化的胞嘧啶（＃4，＃5，＃14）轉化為(wei) 尿嘧啶並檢測為(wei) 胸腺嘧啶，而甲基化的胞嘧啶（＃8）保持相同。

原理和程序
Methylamp RNA亞(ya) 硫酸氫鹽轉換試劑盒包含RNA樣品上快速有效的亞(ya) 硫酸氫鹽轉化所需的所有試劑。*的轉換混合溶液含有強大的RNA保護試劑，可防止化學和嗜熱降解，從(cong) 而加速所有胞嘧啶轉化為(wei) 尿嘧啶，甲基胞嘧啶脫氨基因可忽略不計。無毒RNA捕獲溶液使RNA能夠與(yu) 柱過濾器緊密結合，因此可以在柱上進行轉化的RNA清洗，以有效去除殘留的亞(ya) 硫酸氫鹽和鹽。

起始材料
從(cong) 各種組織或細胞樣品中分離的RNA可用作起始材料。每個(ge) 亞(ya) 硫酸氫鹽反應的RNA量可以是5ng至1μg。為(wei) 獲得適反應，輸入RNA量應為(wei) 200 ng至500 ng。當使用Methylamp RNA亞(ya) 硫酸氫鹽轉換試劑盒進行甲基化特異性RT-PCR和少量輸入RNA（<10 ng）時，PCR循環次數應大於(yu) 45.亞(ya) 硫酸氫鹽轉化後純化的RNA產(chan) 量取決(jue) 於(yu) 輸入RNA的量，RNA的性質和起始材料的來源。

 

 

產(chan) 品組件

 

轉化緩衝(chong) 液：8 ml 
轉化粉：5瓶
NA結合溶液：13 ml 
F-Spin柱：50 
F-收集管：50 
脫磺化溶液：300μl 
對照引物-F（10 uM）：10μl 
對照引物-R（10 uM）10μl 
洗脫緩衝(chong) 液：1.2ml

*在將柱子放入微量離心機之前，始終蓋上旋轉柱

 

 

 

 

Cat. #

Antibody Panel Pack

Modifications

Sizes Each

C10000

 Histone H3 Methylation Antibody Panel Pack I- Active Genes

 H3K4me2

H3K4me3

H3K36me2

H3K36me3

 

25 µg

C10001

 Histone H3 Methylation Antibody Panel Pack I - Repression Genes

 H3K9me2

H3K9me3

H3K27me2

H3K27me3

 

25 µg

C10002

 Histone H3 Methylation Antibody Panel Pack II - Active Genes

 H3K4me3

H3K36me3

H3K79me3

 

 

25 µg

C10003

 Histone H3 Methylation Antibody Panel Pack II - Repression Genes

 H3R2me2a

H3R2me2s

H3R8me2a

H3R8me2s

 

25 µg

C10004

 Histone H3 Methylation Antibody Panel Pack III - Active Genes

 H3R17me2a 

H3R17me2s 

H3R26me2a 

H3R26me2s

 

25 µg

C10005

 Histone H3K4 Methylation Antibody Panel Pack

 H3K4me1

H3K4me2

H3K4me3

 

 

25 µg

C10006

 Histone H3K9 Methylation Antibody Panel Pack

 H3K9me1

H3K9me2

H3K9me3

 

 

25 µg

C10007

 Histone H3K27 Methylation Antibody Panel Pack

 H3K27me1

H3K27me2

H3K27me3

 

 

25 µg

C10008

 Histone H3K36 Methylation Antibody Panel Pack

 H3K36me1

H3K36me2

H3K36me3

 

 

25 µg

C10009

 Histone H3K79 Methylation Antibody Panel Pack

 H3K79me1

H3K79me2

H3K79me3

 

 

25 µg

C10010

 Histone H3 Acetylation Antibody Panel Pack I

 H3K9ac

H3K14ac

H3K18ac

H3K27ac

 

25 µg

C10011

 Histone H3 Acetylation Antibody Panel Pack II

 H3K23ac

H3K36ac

H3K56ac

H3K79ac

 

25 µg

C10012

 Histone H4K20 Methylation Antibody Panel Pack

 H4K20me1

H4K20me2

HH4K20me3

 

 

25 µg

C10013

 Histone H4 Acetylation Antibody Panel Pack

 H4Kc

H4K8ac

H4K12ac

H4K16ac

 

25 µg

C10014

 Histone H3 Phosphorylation Antibody Panel Pack

 H3Ser10

H3Ser28

H3Thr11

 

 

25 µg

C10015

 Histone H3R2 Methylation Antibody Panel Pack

 H3R2me1

H3R2me2a

H3R2me2s

 

 

25 µg

C10016

 Histone H3R8 Methylation Antibody Panel Pack

 H3R8me1

H3R8me2a

H3R8me2s

 

 

25 µg

C10017

 Histone H3R17 Methylation Antibody Panel Pack

 H3R17me1

H3R17me2a

H3R17me2s

 

 

25 µg

C10018

 Histone H3R26 Methylation Antibody Panel Pack

 H3R26me1

H3R26me2a

H3R26me2s

 

 

25 µg

C10019

 Histone H4R3 Methylation Antibody Panel Pack

 H4R3me1

H4R3me2a

H4R3me2s

 

 

25 µg

Image

Description

Cat. No.

Size

Price

 

5-Hydroxymethylcytosine (5-hmC) Monoclonal Antibody [HMC/4D9]
For antibody-based applications requiring high specificity to hydroxymethylated cytosines

Application:

DB, ELISA, IF, IHC, MeDIP

Areas of Research:

Methylation

Clonality:

Monoclonal

Conjugate:

Unconjugated

Host:

Mouse

Isotype:

IgG1

Purification:

Affinity Purified

Reactivity:

Broad Range

 

A-1018-010

10 µg

A-1018-050

50 µg

A-1018-100

100 µg

Availability: Usually Ships In 1-2 Days

Antibodies

5-Methylcytosine (5-mC) Monoclonal Antibody [33D3]
For antibody-based applications requiring high specificity to methylated cytosines
 | 

Application:

DB, ELISA, IF, IHC, IP, MeDIP

Areas of Research:

Methylation

Clonality:

Monoclonal

Conjugate:

Unconjugated

Host:

Mouse

Isotype:

IgG1

Purification:

Affinity Purified

Reactivity:

Broad Range

 

A-1014-010

10 µg

A-1014-050

50 µg

A-1014-100

100 µg

Availability: Usually Ships in 1 Day or  Same Day NY Delivery

Antibodies

ALKBH3 Polyclonal Antibody

Application:

WB

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Unconjugated

Host:

Rabbit

Isotype:

IgG

Purification:

Affinity Purified

Reactivity:

Human, Mouse, Rat

 

A-2723-050

50 µg

A-2723-100

100 µg

Availability: Usually Ships in 3-4 Days

Antibodies

ALKBH3 Polyclonal Antibody

Application:

ELISA, IF, IHC

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Unconjugated

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

Trial Size Available:

Yes

 

A57365-020

20 µg

A57365-050

50 µg

A57365-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

ALKBH3 Polyclonal Antibody, Biotin Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Biotin

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

 

A57368-050

50 µg

A57368-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

ALKBH3 Polyclonal Antibody, FITC Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

FITC

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

 

A57367-050

50 µg

A57367-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

ALKBH3 Polyclonal Antibody, HRP Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

HRP

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

 

A57366-050

50 µg

A57366-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

apaLIM Polyclonal Antibody

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Unconjugated

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Acetobacter pasteurianus

Trial Size Available:

Yes

 

A50869-020

20 µg

A50869-050

50 µg

A50869-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

apaLIM Polyclonal Antibody, Biotin Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Biotin

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Acetobacter pasteurianus

 

A50872-050

50 µg

A50872-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

apaLIM Polyclonal Antibody, FITC Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

FITC

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Acetobacter pasteurianus

 

A50871-050

50 µg

A50871-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

apaLIM Polyclonal Antibody, HRP Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

HRP

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Acetobacter pasteurianus

 

A50870-050

50 µg

A50870-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

APOBEC3A Polyclonal Antibody

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Unconjugated

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

Trial Size Available:

Yes

 

A58106-020

20 µg

A58106-050

50 µg

A58106-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

APOBEC3A Polyclonal Antibody, Biotin Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Biotin

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

 

A58107-050

50 µg

A58107-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

APOBEC3A Polyclonal Antibody, FITC Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

FITC

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

 

A58108-050

50 µg

A58108-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

APOBEC3A Polyclonal Antibody, HRP Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

HRP

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

 

A58109-050

50 µg

A58109-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

CGBP Polyclonal Antibody

Application:

ELISA, IF, IP, WB

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Unconjugated

Host:

Rabbit

Isotype:

IgG

Purification:

Affinity Purified

Reactivity:

Human, Mouse, Rat

 

A-1013-050

50 µg

A-1013-100

100 µg

Availability: Usually Ships In 1-2 Days

Antibodies

CGGBP1 Polyclonal Antibody

Application:

ELISA, IHC

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Unconjugated

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

Trial Size Available:

Yes

 

A68018-020

20 µg

A68018-050

50 µg

A68018-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

CGGBP1 Polyclonal Antibody, Biotin Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Biotin

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

 

A68021-050

50 µg

A68021-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

CGGBP1 Polyclonal Antibody, FITC Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

FITC

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

 

A68020-050

50 µg

A68020-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

CGGBP1 Polyclonal Antibody, HRP Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

HRP

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

 

A68019-050

50 µg

A68019-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

 

DNMT1 Monoclonal Antibody [60B1220.1]

Application:

ELISA, IF, IP, WB

Areas of Research:

Methylation

Clonality:

Monoclonal

Conjugate:

Unconjugated

Host:

Mouse

Isotype:

IgG1

Purification:

Affinity Purified

Reactivity:

Human, Mouse

 

A-1001-050

50 µg

A-1001-100

100 µg

Availability: Usually Ships in 1 Day or  Same Day NY Delivery

Antibodies

DNMT1 Polyclonal Antibody

Application:

ChIP, IF, IHC, IP, WB

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Unconjugated

Host:

Rabbit

Isotype:

IgG

Purification:

Affinity Purified

Reactivity:

Human, Mouse, Rat

 

A-1700-050

50 µg

A-1700-100

100 µg

Availability: Usually Ships in 3-4 Days

Antibodies

DNMT2 Polyclonal Antibody

Application:

IHC, WB

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Unconjugated

Host:

Rabbit

Isotype:

IgG

Purification:

Affinity Purified

Reactivity:

Human, Mouse

 

A-1002-050

50 µl

A-1002-100

100 µl

Availability: Usually Ships in 3-4 Days

Antibodies

DNMT3A Polyclonal Antibody

Application:

IF, IHC, WB

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Unconjugated

Host:

Rabbit

Isotype:

IgG

Purification:

Affinity Purified

Reactivity:

Human, Mouse, Rat

 

A-1003-050

50 µg

A-1003-100

100 µg

Availability: Usually Ships in 3-4 Days

Antibodies

DNMT3A Polyclonal Antibody

Application:

ELISA, IF, IHC

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Unconjugated

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human, Mouse

Trial Size Available:

Yes

 

A52569-020

20 µg

A52569-050

50 µg

A52569-100

100 µg

Availability: Usually Ships Within 1 Week

Antibodies

DNMT3A Polyclonal Antibody, Biotin Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Biotin

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

 

A52572-050

50 µg

A52572-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

DNMT3A Polyclonal Antibody, FITC Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

FITC

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

 

A52571-050

50 µg

A52571-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

DNMT3A Polyclonal Antibody, HRP Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

HRP

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

 

A52570-050

50 µg

A52570-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

DNMT3B Polyclonal Antibody

Application:

WB

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Unconjugated

Host:

Rabbit

Isotype:

IgG

Purification:

Affinity Purified

Reactivity:

Human, Mouse

 

A-1004-050

50 µg

A-1004-100

100 µg

Availability: Usually Ships In 1-2 Days

Antibodies

DNMT3L Monoclonal Antibody [B0-5]

Application:

ICC, IHC

Areas of Research:

Methylation

Clonality:

Monoclonal

Conjugate:

Unconjugated

Host:

Mouse

Isotype:

IgG1

Purification:

Protein G Purified

Reactivity:

Human, Mouse

 

A-1800-100

100 µl

Availability: Usually Ships Within 1-2 Weeks

Antibodies

DNMT3L Polyclonal Antibody

Application:

IF, IP, WB

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Unconjugated

Host:

Rabbit

Isotype:

IgG

Purification:

Affinity Purified

Reactivity:

Human

 

A-1005-050

50 µg

A-1005-100

100 µg

Availability: Usually Ships in 3-4 Days

Antibodies

ecoRVM Polyclonal Antibody

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Unconjugated

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Escherichia coli

Trial Size Available:

Yes

 

A57405-020

20 µg

A57405-050

50 µg

A57405-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

ecoRVM Polyclonal Antibody, Biotin Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Biotin

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Escherichia coli

 

A57408-050

50 µg

A57408-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

ecoRVM Polyclonal Antibody, FITC Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

FITC

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Escherichia coli

 

A57407-050

50 µg

A57407-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

ecoRVM Polyclonal Antibody, HRP Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

HRP

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Escherichia coli

 

A57406-050

50 µg

A57406-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

GATAD2A Polyclonal Antibody 

Application:

ELISA, IHC, WB

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Unconjugated

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human, Rat

Trial Size Available:

Yes

 

A69019-020

20 µg

A69019-050

50 µg

A69019-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

GATAD2A Polyclonal Antibody, Biotin Conjugated 

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Biotin

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

 

A69022-050

50 µg

A69022-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

GATAD2A Polyclonal Antibody, FITC Conjugated 

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

FITC

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

 

A69021-050

50 µg

A69021-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

GATAD2A Polyclonal Antibody, HRP Conjugated 

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

HRP

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

 

A69020-050

50 µg

A69020-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

HINFP Polyclonal Antibody 

Application:

ELISA, WB

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Unconjugated

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human, Rat

Trial Size Available:

Yes

 

A69539-020

20 µg

A69539-050

50 µg

A69539-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

 

HINFP Polyclonal Antibody, Biotin Conjugated 

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Biotin

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

 

A69542-050

50 µg

A69542-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

HINFP Polyclonal Antibody, FITC Conjugated 

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

FITC

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

 

A69541-050

50 µg

A69541-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

HINFP Polyclonal Antibody, HRP Conjugated 

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

HRP

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

 

A69540-050

50 µg

A69540-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

MBD1 Polyclonal Antibody

Application:

E, IF, IP, WB

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Unconjugated

Host:

Rabbit

Isotype:

IgG

Purification:

Affinity Purified

Reactivity:

Human, Mouse, Rat

 

A-1006-050

50 µg

A-1006-100

100 µg

Availability: Usually Ships In 1-2 Days

Antibodies

MBD2 Polyclonal Antibody

Application:

WB

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Unconjugated

Host:

Rabbit

Isotype:

IgG

Purification:

Affinity Purified

Reactivity:

Mouse

 

A-1713-050

50 µg

A-1713-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

MBD3 Polyclonal Antibody

Application:

WB

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Unconjugated

Host:

Rabbit

Isotype:

IgG

Purification:

Affinity Purified

Reactivity:

Human

 

A-1008-050

50 µg

A-1008-100

100 µg

Availability: Usually Ships in 3-4 Days

Antibodies

MBD5 Polyclonal Antibody

Application:

ELISA, WB

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Unconjugated

Host:

Rabbit

Isotype:

IgG

Purification:

Affinity Purified

Reactivity:

Human, Mouse, Rat

 

A-3729-050

50 µl

A-3729-100

150 µl

Availability: Usually Ships Within 1-2 Weeks

Antibodies

MBD5 Polyclonal Antibody

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Unconjugated

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

Trial Size Available:

Yes

 

A67422-020

20 µg

A67422-050

50 µg

A67422-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

MBD5 Polyclonal Antibody, Biotin Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Biotin

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

 

A67425-050

50 µg

A67425-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

MBD5 Polyclonal Antibody, FITC Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

FITC

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

 

A67424-050

50 µg

A67424-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

MBD5 Polyclonal Antibody, HRP Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

HRP

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

 

A67423-050

50 µg

A67423-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

MeCP2 Polyclonal Antibody

Application:

IF, IHC, WB

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Unconjugated

Host:

Rabbit

Isotype:

IgG

Purification:

Affinity Purified

Reactivity:

Human, Mouse, Rat

 

A-1012-050

50 µg

A-1012-100

100 µg

Availability: Usually Ships In 1-2 Days

Antibodies

N6AMT2 Polyclonal Antibody

Application:

ELISA, WB

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Unconjugated

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

Trial Size Available:

Yes

 

A51061-020

20 µg

A51061-050

50 µg

A51061-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

N6AMT2 Polyclonal Antibody, Biotin Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Biotin

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

 

A51064-050

50 µg

A51064-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

N6AMT2 Polyclonal Antibody, FITC Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

FITC

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

 

A51063-050

50 µg

A51063-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

N6AMT2 Polyclonal Antibody, HRP Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

HRP

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

 

A51062-050

50 µg

A51062-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

sacIM Polyclonal Antibody

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Unconjugated

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Streptomyces achromogenes

Trial Size Available:

Yes

 

A57469-020

20 µg

A57469-050

50 µg

A57469-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

sacIM Polyclonal Antibody, Biotin Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Biotin

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Streptomyces achromogenes

 

A57472-050

50 µg

A57472-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

sacIM Polyclonal Antibody, FITC Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

FITC

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Streptomyces achromogenes

 

A57471-050

50 µg

A57471-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

sacIM Polyclonal Antibody, HRP Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

HRP

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Streptomyces achromogenes

 

A57470-050

50 µg

A57470-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

 

scaIM Polyclonal Antibody

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Unconjugated

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Streptomyces caespitosus

Trial Size Available:

Yes

 

A56851-020

20 µg

A56851-050

50 µg

A56851-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

scaIM Polyclonal Antibody, Biotin Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Biotin

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Streptomyces caespitosus

 

A56854-050

50 µg

A56854-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

scaIM Polyclonal Antibody, FITC Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

FITC

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Streptomyces caespitosus

 

A56853-050

50 µg

A56853-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

scaIM Polyclonal Antibody, HRP Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

HRP

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Streptomyces caespitosus

 

A56852-050

50 µg

A56852-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

TET1 Polyclonal Antibody

Application:

IP, WB

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Unconjugated

Host:

Rabbit

Isotype:

IgG

Purification:

Affinity Purified

Reactivity:

Human, Mouse, Rat

 

A-1020-050

50 µg

A-1020-100

100 µg

Availability: Usually Ships in 3-4 Days

Antibodies

TET2 Polyclonal Antibody

Application:

IHC, WB

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Unconjugated

Host:

Rabbit

Isotype:

IgG

Purification:

Affinity Purified

Reactivity:

Human, Mouse, Rat

 

A-1701-050

50 µg

A-1701-100

100 µg

Availability: Usually Ships in 3-4 Days

Antibodies

TET3 Polyclonal Antibody

Application:

ELISA, IHC

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Unconjugated

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

Trial Size Available:

Yes

 

A50520-020

20 µg

A50520-050

50 µg

A50520-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

TET3 Polyclonal Antibody, Biotin Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

Biotin

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

 

A50523-050

50 µg

A50523-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

TET3 Polyclonal Antibody, FITC Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

FITC

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

 

A50522-050

50 µg

A50522-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

Antibodies

TET3 Polyclonal Antibody, HRP Conjugated

Application:

ELISA

Areas of Research:

Methylation

Clonality:

Polyclonal

Conjugate:

HRP

Host:

Rabbit

Isotype:

IgG

Purification:

>95%, Protein G Purified

Reactivity:

Human

 

A50521-050

50 µg

A50521-100

100 µg

Availability: Usually Ships Within 1-2 Weeks

 

 

 

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